The last catalog released of HII regions from CALIFA survey comprises the information of 27000 objects. In previous work, we explored the dependence on the distribution of HII regions sample on the BPT diagram with the morphological type and galactocentric distance. We found a relation between the strong emission lines of nebulae and the subjacent stellar populations' properties. In this work, we present the physical properties from HII regions sample: oxygen abundance, ionization parameter, the fraction of young stellar population, nitrogen-oxygen ratio, electronic density, and dust extinction (Av). We analyzed the dependence between the physical properties and the galactocentric distance, the morphological type, and the stellar mass of the respective host galaxies. We found a relation between the oxygen abundance of HII regions and the age and metallicity of underlying stellar populations.